tailieunhanh - Chemical constituents and their biological activity of Pinus dalatensis

Seven terpenoids were isolated from the dried leaves of Pinus dalatensis Ferré, including one caryolane sesquiterpenoid (1), five labdane diterpenoids (2, 3, 4, 5, 6) and one serratane triterpenoid (7). The structures of the isolated compounds were determined on the basic of spectroscopic methods (ESI-MS, NMR) and comparison with reported data. Among these compounds, the mixture of compounds 2 and 3 showed inhibitory effects on the growth of acute myeloid leukemia (OCI-AML) cells. This is the first report on the chemical compositions of Pinus dalatensis in Vietnam. | Vietnam Journal of Chemistry, International Edition, 55(4): 509-513, 2017 DOI: Chemical constituents and their biological activity of Pinus dalatensis Part 1. Terpenoids from the leaves Nguyen Hoang Sa2,3, Nguyen Thanh Tam1,2, Tran Duc Quan1, Bui Xuan Tinh4, Dao Duc Thien1, Tran Van Sung1, Sabrina Adorisio5, Domenico V Delfino5,6, Trinh Thi Thuy1,2* 1 Institute of Chemistry, Vietnam Academy of Science and Technology 2 Graduate University of Science and Technology, Vietnam Academy of Science and Technology 3 Khanh Hoa University 4 Quang Trung University 5 Section of Pharmacology 6 Foligno Nursing School, Department of Medicine, University of Perugia, Perugia, Italy Received 15 July 2017; Accepted for publication 28 August 2017 Abstract Seven terpenoids were isolated from the dried leaves of Pinus dalatensis Ferré, including one caryolane sesquiterpenoid (1), five labdane diterpenoids (2, 3, 4, 5, 6) and one serratane triterpenoid (7). The structures of the isolated compounds were determined on the basic of spectroscopic methods (ESI-MS, NMR) and comparison with reported data. Among these compounds, the mixture of compounds 2 and 3 showed inhibitory effects on the growth of acute myeloid leukemia (OCI-AML) cells. This is the first report on the chemical compositions of Pinus dalatensis in Vietnam. Keywords. Pinus dalatensis, serratane triterpenoid, caryolane sesquiterpenoid, labdane diterpenoid, acute myeloid leukemia, antiproliferative effect. 1. INTRODUCTION to evaluate the antiproliferative activity of the major compounds from P. dalatensis leaves. Pinaceae is the largest family of conifers comprised of 11 genera including 225 species. There are about 114 species, which belong to the genus Pinus [1]. P. dalatensis is an endemic plant mostly distributed in Lam Dong province of Vietnam. It is a large tree growing up to 40 m high. The needles are finely serrated, 4–10 cm long and in bundles of five. The cones are slender,