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The effect of 3-methylcholanthrene and butylated hydroxytoluene on glycogen levels of liver, muscle, testis, and tumor tissues of rats

This study examined the effects of separate and combined applications of 3-methylcholanthrene, a polycyclic aromatic hydrocarbon and potent carcinogenic agent, and butylated hydroxytoluene, the antioxidant food additive, on the glycogen levels of liver, muscle, testis, and tumor tissues in rats. | Turkish Journal of Biology Turk J Biol (2013) 37: 33-38 © TÜBİTAK doi:10.3906/biy-1010-126 http://journals.tubitak.gov.tr/biology/ Research Article The effect of 3-methylcholanthrene and butylated hydroxytoluene on glycogen levels of liver, muscle, testis, and tumor tissues of rats 1, 2 3 4 5 6 Fikriye POLAT *, Egemen DERE , Eylem GÜL , İzzet YELKUVAN , Öztürk ÖZDEMİR , Günsel BİNGÖL 1 Department of Education, Faculty of Education, Kocaeli University, Kocaeli, Turkey 2 Department of Biology, Faculty of Arts and Sciences, Uludağ University, Bursa, Turkey 3 Forensic Medicine Institute, Cerrahpaşa Faculty of Medicine, İstanbul University, İstanbul, Turkey 4 Department of Medical Biology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey 5 Department of Medical Genetics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey 6 Health Sciences, Dialysis Program, Nişantaşı University, İstanbul, Turkey Received: 20.10.2010 Accepted: 19.07.2012 Published Online: 10.01.2013 Printed: 01.02.2013 Abstract: This study examined the effects of separate and combined applications of 3-methylcholanthrene, a polycyclic aromatic hydrocarbon and potent carcinogenic agent, and butylated hydroxytoluene, the antioxidant food additive, on the glycogen levels of liver, muscle, testis, and tumor tissues in rats. Adult male Wistar albino rats weighing 100–110 g at 8 weeks of age were used in this study. This study consisted of a control group (n = 9) and 3 different experiment groups in which rats were chronically treated with 3-methylcholanthrene (n = 9) or butylated hydroxytoluene (n = 11) or a combination of these agents (n = 14). Rats were intraperitoneally injected with a 200 mg kg−1 dose of butylated hydroxytoluene and a 40 mg kg–1 dose of 3-methylcholanthrene. At the end of the 26-week experimental period, tissues of rats killed via cervical dislocation were placed in 10% trichloroacetic acid for glycogen determination. Our results showed that .