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Further chemical constituents of Scoparia dulcis L. (Scrophulariaceae) originating in Vietnam

The volatile fraction of S. dulcis was analyzed by GC-MS to show the accumulation of methyl esters of fatty acids. The useful compound methoxybenzoxazolinone (MBOA) was found to be localized in the CH2Cl2- soluble fraction of the MeOH extract. For the direct qualitative and quantitative evaluation of MBOA in the CH2Cl2-soluble fraction 1 H-NMR method was applied in this study. | Journal of Chemistry, Vol. 47 (5), P. 640 - 646, 2009 FURTHER CHEMICAL CONSTITUENTS OF SCOPARIA DULCIS L. (SCROPHULARIACEAE) ORIGINATING IN VIETNAM Received 25 May 2009 1 PHAN MINH GIANG , DANG THI HUYNH NGA1,2, NGUYEN XUAN HAI1, PHAN TONG SON1 1 Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, Vietnam 2 National Institute of Nutrition, Hanoi, Vietnam abstract Palmitic acid (1), β-sitosterol (2), glutinol (3), and a mixture of β-amyrin (4) and isomultiflorenol (5), whose structures were determined by using spectroscopic methods, were isolated from the aerial parts of Scoparia dulcis L. (Scrophulariaceae). The volatile fraction of S. dulcis was analyzed by GC-MS to show the accumulation of methyl esters of fatty acids. The useful compound methoxybenzoxazolinone (MBOA) was found to be localized in the CH2Cl2soluble fraction of the MeOH extract. For the direct qualitative and quantitative evaluation of MBOA in the CH2Cl2-soluble fraction 1H-NMR method was applied in this study. Antimicrobial test of the soluble fractions and MBOA showed inhibition on Escherichia coli, Pseudomonas aeruginosa, and Saccharomyces cerevisiae. Keywords: Scoparia dulcis; Scrophulariaceae; triterpenoid; methoxybenzoxazolinone (MBOA). I - INTRODUCTION The production of secondary metabolites in plants is recognized as an important source for pharmacologically useful compounds. Therefore the full knowledge of chemical profiles of medicinal plants should be the scientific basis for understanding safety and efficacy of many plant-derived pharmaceutical products. In addition, the chemical profiles of many plants are known to be dependent on growth conditions [1]. One of the aims of our study program on Vietnamese medicinal plants is to have comprehensive chemical profiles of the plants; as a result of the studies a variety of apolar and polar compounds have already been found and reported [2a-e]. Scoparia dulcis L. (Scrophulariaceae) is a medicinal herb .