tailieunhanh - Further study on chemical constituents and biological activities of alpinia conchigera griff (Zingiberaceae)

-Sitosterol, stigmasterol, cardamomin (1), chalconaringenin 2-O-methyl ether (2), alpinetin (3), and naringenin 5-O-methyl ether (4) were isolated from the MeOH extract of Alpinia conchigera Griff. (Zingiberaceae). Their structures were determined on the basis of spectroscopic analyses. The antimicrobial and free radical scavenging activities of the isolates 1-4 were evaluated in correlation with those of the soluble fractions. | Journal of Chemistry Vol. 45 2 P. 260 - 264 2007 FURTHER STUDy ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF ALPINIA CQNCHIGERA GRIFF. ZINGIBERACEAE Received 22 Sep. 2006 LE HUyEN TRAM PHAN MINH GIANG PHAN TONG SON Laboratory of Chemistry of Natural Products Faculty of Chemistry College of Natural Science Vietnam National University Hanoi Vietnam SUMMARy 3-Sitosterol stigmasterol cardamomin 1 chalconaringenin 2 -O-methyl ether 2 alpinetin 3 and naringenin 5-O-methyl ether 4 were isolated from the MeOH extract of Alpinia conchigera Griff. Zingiberaceae . Their structures were determined on the basis of spectroscopic analyses. The antimicrobial and free radical scavenging activities of the isolates 1-4 were evaluated in correlation with those of the soluble fractions. Key words Alpinia conchigera Zingiberaceae chalcone flavanone antimicrobial activity free radical scavenging activity I - INTRODUCTION The medicinal plant Alpinia conchigera Griff. of family Zingiberaceae Vietnamese name Rieng rung is a very attractive target for the chemical and biological studies. Flavones flavanones chalcones diarylheptanoids phenylpropanoids and carbohydrates were isolated from the rhizomes and fruits of the species 1-3 . Our previous investigation revealed the isolation of the chalcone cardamomin 1 as the main constituent of the EtOH extract of the rhizomes of A. conchigera growing in Vietnam 1 . The finding will be of high interest since the blockade of nuclear factor-kappa B signaling pathway and anti- inflammatory activity of cardamomin were clearly demonstrated in our study 4 . In a continuation of the study we report in this paper the isolation of -sitosterol stigmasterol cardamomin 1 chalconaringenin 2 -O-methyl ether 2 alpinetin 3 and naringenin 5-O- 260 methyl ether 4 from the MeOH extract of A. conchigera and the antimicrobial and free radical scavenging activities of the isolates 1-4 in correlation with those of the soluble fractions of the MeOH extract. II - .

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