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Stilbene, Ferulic acid and its derivatives from the roots of Angelica sinensis

The rhizome of Angelica sinensis (Oliv.) Diels (Umbelliferae) is one of the most commonly used traditional drugs in China, indicated against anemia, menstrual disorders, amenorroehea and rheumatism. From the ethyl acetate extract of the roots of A. sinensis a stilbene, ferulic acid, coniferylferulate and decorticate have been isolated. Their structures were identified by MS and NMR spectroscopic methods. | Tạp chí Hóa học T. 42 4 Tr. 508 - 511 2004 STILBENE FERULIC ACID AND ITS DERIVATIVES FROM THE ROOTS OF ANGELICA SINENSIS Received 17-11-2003 NGUyEN THI HONG VAN1 NGUyEN THI HOANG ANH1 TRAN VAN SUNG1 KATRIN FRANKE2 AND LUDGER WESSJQHANN2 institute of Chemistry National Center for Natural Science and Technology 2Institute of Plant Biochemistry Halle S. Germany SUMMARY The rhizome of Angelica sinensis Oliv. Diels Umbelliferae is one of the most commonly used traditional drugs in China indicated against anemia menstrual disorders amenorroehea and rheumatism. From the ethyl acetate extract of the roots of A. sinensis a stilbene ferulic acid coniferylferulate and decorticate have been isolated. Their structures were identified by MS and NMR spectroscopic methods. I - INTRODUCTION The roots of Angelica sinensis are also known as Danggui in China. In China it serves as remedy against anemia menstrual disorders amenorroehea and rheumatism 1 . In the Vietnamese folk medicine it is used for the treatment of constipation and pain 2 . In Japan Angelica acutiloba is used as a substitute for A. sinensis. Research reports on the analysis its ingredients are appeared in the literature since 1924. Recently many advances have been made in chemical and pharmacological studies of this drug. A series of components have been found in the roots of A. sinensis by GC HPLC-MS analysis. 53 constituents in its essential oil and 34 compounds in non-volatile fraction have been reported by Chen Yaozu 3 . Z-ligustilide is the main component and coniferyl ferulate butylphthalide etc. are the major components. The present communication deals with the isolation and structural elucidation of four compounds 1-4 . Their structures have been determined by MS 1H and 13C-NMR spectroscopy and by comparison with the data published in the literature to be 4 4 -dihydroxy 3 3 -dimethoxy stilben 1 ferulic acid 2 coniferylferulate 3 and decorticate 4 . II - EXPERIMENTAL 1. Plant material The roots of A. sinensis