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Sách: British Guideline on the Management of Asthma

System and Information Owners. The system and information owners are responsible for ensuring that proper controls are in place to address integrity, confidentiality, and availability of the IT systems and data they own. Typically the system and information owners are responsible for changes to their IT systems. Thus, they usually have to approve and sign off on changes to their IT systems (e.g., system enhancement, major changes to the software and hardware). The system and information owners must therefore understand their role in the risk management process and fully support this process | Healthcare 1 Improvement F Scotland SIGN Scottish Intercollegiate Guidelines Network 101 British Guideline on the Management of Asthma A national clinical guideline May 2008 Revised January 2012 KEY TO EVIDENCE STATEMENTS AND GRADES OF RECOMMENDATIONS LEVELS OF EVIDENCE 1 High quality meta-analyses systematic reviews of RCTs or RCTs with a very low risk of bias 1 Well conducted meta-analyses systematic reviews or RCTs with a low risk of bias 1- Meta-analyses systematic reviews or RCTs with a high risk of bias High quality systematic reviews of case control or cohort studies 2 High quality case control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal 2 Well conducted case control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal 2 - Case control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal 3 Non-analytic studies eg case reports case series 4 Expert opinion GRADES OF RECOMMENDATION Note The grade of recommendation relates to the strength of the evidence on which the recommendation is based. It does not reflect the clinical importance of the recommendation. A At least one meta-analysis systematic review or RCT rated as 1 and directly applicable to the target population or A body of evidence consisting principally of studies rated as 1 directly applicable to the target population and demonstrating overall consistency of results B A body of evidence including studies rated as 2 directly applicable to the target population and demonstrating overall consistency of results or Extrapolated evidence from studies rated as 1 or 1 C A body of evidence including studies rated as 2 directly applicable to the target population and demonstrating overall consistency of results or Extrapolated evidence from studies rated as 2 D Evidence level 3 or 4 or Extrapolated evidence from .