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Can’t Shake that Feeling: Event-Related fMRI Assessment of Sustained Amygdala Activity in Response to Emotional Information in Depressed Individuals

However, those runners who have the patience to develop speed for shorter distances will realise even greater benefits when they decide to take the step up the marathon. Building speed before endurance is always the best method of enhancing long-term performance. This article will give you a taste of speed training as it includes an eight-week training program designed to develop your running so you can complete a 10k race in your desired time. The program assumes a basic level of fitness, allowing you to complete the first week relatively comfortably. If you feel as though you might. | Original Articles Can t Shake that Feeling Event-Related fMRI Assessment of Sustained Amygdala Activity in Response to Emotional Information in Depressed individuals Greg J. Siegle Stuart R. Steinhauer Michael E. Thase V. Andrew Stenger and Cameron S. Carter Background Previous research suggests that depressed individuals engage in prolonged elaborative processing of emotional information. A computational neural network model of emotional information processing suggests this process involves sustained amygdala activity in response to processing negative features of information. This study examined whether brain activity in response to emotional stimuli was sustained in depressed individuals even following subsequent distracting stimuli. Methods Seven depressed and 10 never-depressed individuals were studied using event-related functional magnetic resonance imaging during alternating 15-sec emotional processing valence identification and nonemotional processing Sternberg memory trials. Amygdala regions were traced on high-resolution structural scans and coregistered to the functional data. The time course of activity in these areas during emotional and nonemotional processing trials was examined. Results During emotional processing trials never-depressed individuals displayed amygdalar responses to all stimuli which decayed within 10 sec. In contrast depressed individuals displayed sustained amygdala responses to negative words that lasted throughout the following nonemotional processing trials 25 sec later . The difference in sustained amygdala activity to negative and positive words was moderately related to self-reported rumination. Conclusions Results suggest that depression is associated with sustained activity in brain areas responsible for coding emotional features. Biol Psychiatry 2002 51 693-707 2002 Society of Biological Psychiatry Key Words Sustained processing depression emotion information processing fMRI rumination From the University of Pittsburgh .