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Báo cáo khoa học: Calpain involvement in the remodeling of cytoskeletal anchorage complexes
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Cells offer different types of cytoskeletal anchorages: transitory structures such as focal contacts and perennial ones such as the sarcomeric cytoskele-ton of muscle cells. The turnover of these structures is controlled with dif-ferent timing by a family of cysteine proteases activated by calcium, the calpains. | ềFEBS Journal MINIREVIEW Calpain involvement in the remodeling of cytoskeletal anchorage complexes Marie-Christine Lebart and Yves Benyamin UMR5539 EPHE-CNRS-UM2 cc107 Universite de Montpellier II France Keywords adhesion calpain cytoskeleton focal complexes ischemia muscle Correspondence M.-C. Lebart UMR5539 EPHE-CNRS-UM2 cc107 Universite de Montpellier II place E. Bataillon 34095 Montpellier cedex 5 France Fax 33 0467144727 Tel 33 0467143889 E-mail mclebart@univ-montp2.fr Received 23 March 2006 accepted 31 May 2006 doi 10.1111 j.1742-4658.2006.05350.x Cells offer different types of cytoskeletal anchorages transitory structures such as focal contacts and perennial ones such as the sarcomeric cytoskeleton of muscle cells. The turnover of these structures is controlled with different timing by a family of cysteine proteases activated by calcium the calpains. The large number of potential substrates present in each of these structures imposes fine tuning of the activity of the proteases to avoid excessive action. This phenomenon is thus guaranteed by various types of regulation ranging from a relatively high calcium concentration necessary for activation phosphorylation of substrates or the proteases themselves with either a favorable or inhibitory effect possible intervention of phospholipids and the presence of a specific inhibitor and its possible degradation before activation. Finally formation of multiprotein complexes containing calpains offers a new method of regulation. Introduction The importance of cytoskeletal anchorages and their renewal is evident in both physiological and pathological situations. During fast processes such as cell shape modification adhesion to extracellular matrix cell migration and growth factor-induced signaling pathways the turnover of anchorage complexes is involved in the rapidity of the response to cell polarization and directional movements. On the other hand adhesive contacts of muscle cells need stabilization of the .