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Handbook of Experimental Pharmacology - Part 3

Kết quả khử cực kích hoạt các cảm biến điện áp và mở kênh, cho phép thông qua ion. Sau đó để kích hoạt kênh, các kênh vào trạng thái bất hoạt không dẫn điện và vật liệu chịu lửa. Tái cực là cần thiết để giảm bớt bất hoạt với thời gian isoformspecific và phụ thuộc vào điện áp. | Pacemaker Current and Automatic Rhythms Toward a Molecular Understanding 65 Boyett MR Dobrzynski H Lancaster MK Jones SA Honjo H Kodama I 2003 Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function. J Cardiovasc Electrophysiol 14 104-106 Brown HF DiFrancesco D 1980 Voltage-clamp investigations of membrane currents underlying pacemaker activity in rabbit sino-atrial node. J Physiol Lond 308 331-351 Bryant SM Sears CE Rigg L Terrar DA Casadei B 2001 Nitric oxide does not modulate the hyperpolarization-activated current If in ventricular myocytes from spontaneously hypertensive rats. Cardiovasc Res 51 51-58 Bucchi A Baruscotti M DiFrancesco D 2002 Current-dependent block of rabbit sino-atrial node I f channels by ivabradine. J Gen Physiol 120 1-13 Bucchi A Baruscotti M Robinson RB DiFrancesco D 2003 If-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells. J Mol Cell Cardiol 35 905-913 Camelliti P Green CR LeGrice I Kohl P 2004 Fibroblast network in rabbit sinoatrial node structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res 94 828-835 Catterall WA 1992 Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72 S15-S48 Cerbai E Barbieri M Mugelli A 1996 Occurrence and properties of the hyperpolarization-activated current If in ventricular myocytes from normotensive and hypertensive rats during aging. Circulation 94 1674-1681 Cerbai E Sartiani L DePaoli P Pino R Maccherini M Bizzarri F DiCiolla F Davoli G Sani G Mugelli A 2001 The properties of the pacemaker current If in human ventricular myocytes are modulated by cardiac disease. J Mol Cell Cardiol 33 441-448 Chang F Gao J Tromba C Cohen I DiFrancesco D 1990 Acetylcholine reverses effects of beta-agonists on pacemaker current in canine cardiac Purkinje fibers but has no direct action. A difference between primary and secondary pacemakers. .