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Báo cáo y học: " Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs. | Available online http ccforum.eom content 1 2 6 R164 Open Access Research Renal haemodynamic microcirculatory metabolic and histopathological responses to peritonitis-induced septic shock in pigs Jiri Chvojka1 Roman Sykora1 Ales Krouzecky1 Jaroslav Radej1 Veronika Varnerova1 Thomas Karvunidis1 Ondrej Hes2 Ivan Novak1 Peter Radermacher3 and Martin Matejovic1 Intensive care unit 1st Medical Department Charles University Medical School and Teaching Hospital Plzen alej Svobody 80 Plzen 304 60 Czech Republic 2Department of Pathology Charles University Medical School and Teaching Hospital Plzen Czech Republic alej Svobody 80 Plzen 304 60 Czech Republic 3Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinikum ParkstraBe 11 Ulm 890 73 Germany Corresponding author Martin Matejovic matejovic@fnplzen.cz Received 15 Sep 2008 Revisions requested 19 Oct 2008 Revisions received 12 Nov 2008 Accepted 24 Dec 2008 Published 24 Dec 2008 Critical Care 2008 12 R164 doi 10.1186 cc7164 This article is online at http ccforum.com content 12 6 R1 64 2008 Chvojka et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Our understanding of septic acute kidney injury AKI remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore we dynamically assessed renal haemodynamic microvascular and metabolic responses to and ultrastructural sequelae of sepsis in a porcine model of faecal peritonitis-induced progressive hyperdynamic sepsis. Methods In eight anaesthetised and mechanically ventilated pigs faecal peritonitis was induced by inoculating autologous faeces. Six sham-operated animals served as time-matched controls. Noradrenaline was .