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DNA METHYLATION – FROM GENOMICS TO TECHNOLOGY
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DNA METHYLATION – FROM GENOMICS TO TECHNOLOGY
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Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3. DNA hypomethylation also contributes to cancer development via three major mechanisms, such as: an increase in genomic instability, reactivation of transposable elements and loss of imprinting | DNA METHYLATION -FROM GENOMICS TO TECHNOLOGY Edited by Tatiana Tatarinova and Owain Kerton INTECHOPEN.COM DNA Methylation - From Genomics to Technology Edited by Tatiana Tatarinova and Owain Kerton Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Iva Simcic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published March 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com DNA Methylation - From Genomics to Technology Edited by Tatiana Tatarinova and Owain Kerton p. cm. ISBN 978-953-51-0320-2 .
TÀI LIỆU LIÊN QUAN
DNA Methylation – From Genomics to Technology Edited by Tatiana Tatarinova and Owain Kerton
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Paternal germ line aging: DNA methylation age prediction from human sperm
Genome-wide DNA methylation patterns of bovine blastocysts derived from in vivo embryos subjected to in vitro culture before, during or after embryonic genome activation
DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield
DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism
DNA methylation changes facilitated evolution of genes derived from Mutator-like transposable elements
The mitochondrial genome and Epigenome of the Golden lion Tamarin from fecal DNA using Nanopore adaptive sequencing
Transcriptome sequencing and metabolome analysis of food habits domestication from live prey fish to artificial diets in mandarin fish (Siniperca chuatsi)
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