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Báo cáo y học: " Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study) | Vieta et al. BMC Psychiatry 2011 11 58 http www.biomedcentral.com 1471-244X 11 58 BMC Psychiatry STUDY PROTOCOL Open Access Clinical management and burden of bipolar disorder a multinational longitudinal study WAVE-bd Study E I I I 1 - 4- s 1 t E I o I c S S I m M I 2 h z rì I I II El z t I I I 31 I r h z I M z i z 1 z n 4t Eduard Vieta Elena Blasco-Colmenares Maria Luisa Figueira Jens M Langosch Miriam Moreno-Manzanaro5t and Esteban Medina 5 for WAVE-bd Study Group Abstract Background Studies in bipolar disorder BD to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and or a specific treatment. Moreover most clinical trials have focused on the manic phase of disease and not on depression which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD I and II and the whole course of the disease regardless of patients symptomatology. Therefore the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder WAVE-bd NCT01062607 aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. Methods WAVE-bd is a multinational multicentre non-interventional longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria Belgium Brazil France Germany Portugal Romania Turkey Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid e.g. academic hospitals private practices in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum .