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Báo cáo khoa học: "RAGE: Exacting a toll on the host in response to polymicrobial sepsis and Listeria monocytogenes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: RAGE: Exacting a toll on the host in response to polymicrobial sepsis and Listeria monocytogenes. | Available online http ccforum.eom content 11 6 183 Commentary RAGE Exacting a toll on the host in response to polymicrobial sepsis and Listeria monocytogenes Raphael Clynes1 Kevan Herold2 and Ann Marie Schmidt3 1 Department of Medicine and Microbiology Columbia University Medical Center 630 West 168th Street New York NY 10032 USA 2Department of Medicine and Immunobiology Yale University School of Medicine 10 Amistad Street 131D New Haven CT 06520 USA 3Division of Surgical Science Department of Surgery Columbia University Medical Center 630 West 168th Street P S 17-401 New York NY 10032 UsA Corresponding author Ann Marie Schmidt ams11@columbia.edu Published 28 December 2007 This article is online at http ccforum.com content 11 6 183 2007 BioMed Central Ltd Critical Care 2007 11 183 doi 10.1186 cc6193 See related research by Lutterloh et al. http ccforum.com content 11 6 R122 Abstract The receptor for advanced glycation endproducts RAGE has complex roles in the immune inflammatory response. RAGE is expressed on monocytes macrophages T and B lymphocytes and dendritic cells. Previous studies illustrated that homozygous RAGE- - mice subjected to overwhelming bacterial sepsis displayed normal clearance of pathogenic bacteria and significantly increased survival. In this issue of Critical Care Lutterloh and colleagues confirm these findings and provide evidence that blocking antibodies to RAGE afford similar protection in mice even when administration of anti-RAGE is delayed by 24 hours. Furthermore these authors illustrate that deletion of RAGE is remarkably protective in mice infected with the intracellular pathogen Listeria monocytogenes. In this Commentary we consider these findings and propose possible mechanisms by which RAGE exacts a heavy toll on the host in response to polymicrobial sepsis and L. monocytogenes. The receptor for advanced glycation endproducts RAGE plays central roles in the immune inflammatory response. In this issue of Critical Care Lutterloh and