Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo khoa học: "Hyperoxic acute lung injury and ventilator-induced/associated lung injury: new insights into intracellular signaling pathways"
Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hyperoxic acute lung injury and ventilator-induced/associated lung injury: new insights into intracellular signaling pathways. | Available online http ccforum.eom content 11 2 126 Commentary Hyperoxic acute lung injury and ventilator-induced associated lung injury new insights into intracellular signaling pathways Claudia C Dos Santos 2Saint Michael s Hospital Department of Critical Care Medicine 30 Bond Street 4-008 Toronto ON M5G 1W8 Canada Corresponding author C C dos Santos dossantosc@smh.toronto.on.ca Published 19 April 2007 This article is online at http ccforum.com content 11 2 126 2007 BioMed Central Ltd Critical Care 2007 11 126 doi 10.1186 cc5733 See related research by Li et al. http ccforum.com content 11 1 R25 Abstract In patients with acute respiratory distress syndrome ARDS supportive therapy with mechanical ventilation and oxygen is often life saving. Further acute lung injury however is an unfortunate consequence of oxygen therapy as well as mechanical injury secondary to ventilator induced associated lung injury VI ALI . In this issue of Critical Care Li et al. expand on the intra-cellular signaling pathways regulating interactions between injury cascades resulting from hyperoxia and high tidal volume ventilation. The findings suggest that interference or cooperation of different signals may have critical consequences as evidenced by indices of increased lung inflammation microvascular permeability and lung epithelial apoptotic cell death. Every patient with acute respiratory distress syndrome ARDS is hypoxemic by definition. In these patients mechanical ventilation MV is often life-saving. Repetitive cyclic stretch however results in regional overdistension or and derecruitment which is associated with a number of severe complications termed ventilator-induced associated lung injury VI ALI 1 . The attributable mortality of VI ALI has been estimated to be at least 9 2 and despite evidence that high concentrations of oxygen fractional inhaled concentrations of oxygen FiO2 greater than 50 can lead to hyperoxic acute lung injury HALI oxygen therapy remains a cornerstone of .