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báo cáo khoa học: " Predictive, preventive, personalized and participatory medicine: back to the future"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Predictive, preventive, personalized and participatory medicine: back to the future | Auffray et al. Genome Medicine 2010 2 57 http genomemedicine.eom content 2 8 57 w Genome Medicine EDITORIAL L_ Predictive preventive personalized and participatory medicine back to the future Charles Auffray1 Dominique Charron2 and Leroy Hood3 Abstract The pioneering work of Jean Dausset on the HLA system established several principles that were later reflected in the Human Genome Project and contributed to the foundations of predictive preventive personalized and participatory P4 medicine. To effectively develop systems medicine we should take advantage of the lessons of the HLA saga emphasizing the importance of exploring a fascinating but mysterious biology now using systems principles pioneering new technology developments and creating shared biological and information resources. HLA and the Human Genome Project Shortly before he passed away last year the late Jean Dausset said he wanted to be remembered for four disciplines to which he had made significant contributions anthropology immune response transplantation and predictive medicine 1 . All of these were based on his seminal discovery of the human leukocyte antigens HLA in the 1950s. In 1980 he received the Nobel Prize in Physiology or Medicine jointly with Baruj Benacerraf and George Snell for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions . Through the international and highly collaborative HLA workshops that he pioneered with colleagues in the 1960s and which have been running successfully ever since Jean Dausset and his colleagues established the important role of the histocompatibility antigens in the control of the immune response and in the susceptibility or resistance to a wide variety of diseases including those with an auto-immune component and they realized that these defined a key element of the biologically unique Correspondence charles.auffray@vjf.cnrs.fr functional Genomics and Systems Biology for Health CNRS