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Báo cáo khoa học: " Children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity. | Available online http ccforum.eom content 10 6 R165 Research Children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity Ruth Heying1 Wim van Oeveren2 Stefanie Wilhelm1 Katharina Schumacher1 Ralph G Grabitz1 Bruno J Messmer3 and Marie-Christine Seghaye1 Department of Pediatric Cardiology University Hospital RWTH-Aachen Pauwelsstrasse 30 52074 Aachen Germany department of BioMedical Engineering University of Groningen A. Deusinglaan1 9713 AV Groningen The Netherlands department of Cardiothoracic and Vascular Surgery University Hospital RWTH-Aachen Pauwelsstrasse 30 52074 Aachen Germany Corresponding author Ruth Heying heying@uni-duesseldorf.de Received 31 Aug 2006 Revisions requested 4 Oct 2006 Revisions received 5 Nov 2006 Accepted 24 Nov 2006 Published 24 Nov 2006 Critical Care 2006 10 R165 doi 10.1186 cc5108 This article is online at http ccforum.com content 10 6 R165 2006 Heying et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Cardiac surgery with cardiopulmonary bypass CPB is associated with the activation of inflammatory mediators that possess prothrombotic activity and could cause postoperative haemostatic disorders. This study was conducted to investigate the effect of cardiac surgery on prothrombotic activity in children undergoing cardiac surgery for complex cardiac defects. Methods Eighteen children ages 3 to 163 months undergoing univentricular palliation with total cavopulmonary connection TCPC n 10 or a biventricular repair n 8 for complex cardiac defects were studied. Prothrombotic activity was evaluated by measuring plasma levels of prothrombin fragment 1 2 F1 2 thromboxane B2 TxB2 and monocyte chemoattractant