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Báo cáo khoa học: "Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia. | Available online http ccforum.eom content 10 5 R144 Research Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia Christian Ertmer1 Andrea Morelli2 Hans-Georg Bone1 Henning Dirk Stubbe1 Ralf Schepers1 Hugo Van Aken1 Matthias Lange1 Katrin Broking1 Martin Lucke3 Daniel L Traber4 and Martin Westphal1 1 Department of Anesthesiology and Intensive Care University Hospital of Muenster Albert-Schweitzer-Strasse 33 48149 Muenster Germany 2Department of Anesthesiology and Intensive Care University of Rome La Sapienza 00185 Rome Italy 3Central Animal Research Facility University Hospital of Muenster Muenster Germany University Hospital of Muenster Albert-Schweitzer-Strasse 33 48149 Muenster Germany 4Investigational Intensive Care Unit University of Texas Medical Branch 301 University Boulevard Galveston TX 77555 USA Corresponding author Martin Westphal martin.westphal@gmx.net Received 21 Jul 2006 Revisions requested 23 Aug 2006 Revisions received 5 Oct 2006 Accepted 10 Oct 2006 Published 10 Oct 2006 Critical Care 2006 10 R144 doi 10.1186 cc5065 This article is online at http ccforum.com content 10 5 R144 2006 Ertmer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Arginine vasopressin AVP is increasingly used to treat sepsis-related vasodilation and to decrease catecholamine requirements. However AVP infusion may be associated with a marked decrease in systemic blood flow and oxygen transport. The purpose of the present study was to evaluate whether dobutamine may be titrated to reverse the AVP-related decrease in cardiac index CI and systemic oxygen delivery index DO2I in an established model of ovine endotoxemia. Methods .