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Báo cáo y học: "The boy who refused an IV: a case report of subcutaneous clodronate for bone pain in a child with Ewing Sarcoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The boy who refused an IV: a case report of subcutaneous clodronate for bone pain in a child with Ewing Sarcoma. | Journal of Medical Case Reports BioMed Central Case report The boy who refused an IV a case report of subcutaneous clodronate for bone pain in a child with Ewing Sarcoma Harold Siden Open Access Address Dept. of Pediatrics University of British Columbia and Canuck Place Children s Hospice Vancouver British Columbia Canada Email Harold Siden - hsiden@cw.bc.ca Corresponding author Published 21 March 2007 Received 14 December 2006 -. Accepted 21 March 2007 Journal of Medical Case Reports 2007 1 7 doi l0.ll86 1752-1947-1-7 This article is available from http www.jmedicalcasereports.cOm content 1 1 7 2007 Siden licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bone pain in malignancy can be challenging to treat. Bisphosphonates have been found to be useful in adults with bone pain but there are no reports of their use in children for this indication. In pediatric palliative medicine there are hurdles in translating knowledge gained primarily in adult studies into application in children. Obstacles exist in initially determining whether the evidence supports using a drug in children and once a drug is chosen then determining the optimal route of delivery. There is very little data to guide pediatric practitioners in this situation. Case Presentation A 9 year old boy with disseminated Ewing Sarcoma presented with extremity pain not responsive to a combination of opiates gabapentin and non-steroidal anti-inflammatory drugs. Clodronate a bisphosphonate was added to the regimen to treat bone pain. It was given subcutaneously every 4 weeks with a good response and no side effects. Conclusion This case report describes the use of a bisphosphonate clodronate given subcutaneously to a child with Ewing sarcoma with .