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Báo cáo khoa học: "Tissue engineered fetal skin constructs for pediatric burns"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Tissue engineered fetal skin constructs for pediatric burns. | Available online http ccforum.eom content 9 6 533 Commentary Tissue engineered fetal skin constructs for pediatric burns William B Norbury1 Marc G Jeschke2 and David N Herndon3 1 Burns Research Fellow Department of Surgery Shriners Hospitals for Children Galveston Texas USA 2Assistant Professor Department of Surgery Shriners Hospitals for Children Galveston Texas USA 3Chief of Staff Professor of Surgery Jesse H Jones Distinguished Chair in Burn Surgery Department of Surgery Shriners Hospitals for Children Galveston Texas USA Corresponding author David N Herndon dherndon@utmb.edu Published online 17 October 2005 This article is online at http ccforum.com content 9 6 533 2005 BioMed Central Ltd Critical Care 2005 9 533-534 DOI 10.1186 cc3881 Abstract The management of patients with partial thickness second degree burns is problematic due to the different treatments needed for varying depths of injury. A report recently published in The Lancet describes a novel treatment for deep second degree burns using a fetal skin construct FSC . The authors included eight pediatric patients with small second degree burns. They showed that FSCs reduced the need for autografting of deep second degree burns with little hypertrophy of new skin and no skin contraction. This technology is new and exciting but in our opinion several issues must be addressed before FSCs can enter the clinical arena. All of the patients were included in the treatment group and therefore no comparison with conventional skin substitutes was possible. There is no mention of the use of laser Doppler in any initial assessment of patients. The debridement carried out before application of the FSC is not elaborated upon and the surface areas involved in the study were very small in most cases which limits the relevance to patients with larger burns. The use of FSCs gives us an additional option in a range of possible treatments for this notoriously difficult-to-treat patient group. Introduction Partial thickness