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Báo cáo khoa học: " Bench-to-bedside review: Iron metabolism in critically ill patients"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Iron metabolism in critically ill patients. | Critical Care October 2004 Vol 8 No 5 Darveau et al. Review Bench-to-bedside review Iron metabolism in critically ill patients Martin Darveau1 2 André Y Denault3 Normand Blais4 and Éric Notebaert5 1 Research student Faculty of Pharmacy University of Montreal Quebec Canada 2Cité de la Santé de Laval Quebec Canada 3Clinical Assistant Professor of Anesthesia University of Montreal Montreal Heart Institute and Centre Hospitalier de l Université de Montréal Québec Canada 4Hematologist Hematology Department Cité de la Santé de Laval Québec Canada 5Clinical Assistant Professor of Medicine Critical Care Department Cité de la Santé de Laval Québec Canada Corresponding author Martin Darveau martin_darveau@ssss.gouv.qc.ca Published online 13 May 2004 Critical Care 2004 8 356-362 DOI 10.1186 cc2862 This article is online at http ccforum.com content 8 5 356 2004 BioMed Central Ltd See Commentary page 306 Abstract Critically ill patients frequently develop anemia due to several factors. Iron-withholding mechanisms caused by inflammation contribute to this anemia. The iron metabolism imbalances described or reported in all intensive care studies are similar to the values observed in anemia of inflammation. The administration of iron could be useful in the optimization of recombinant human erythropoietin activity but this could be at the expense of bacterial proliferation. Since there is a lack of evidence to support either oral or intravenous iron administration in intensive care patients further studies are necessary to determine the efficacy and safety of iron supplementation in conjunction with recombinant human erythropoietin in critically ill patients. We review the mechanisms leading to iron sequestration in the presence of inflammation. The present article also reviews the literature describing the iron status in critically ill patients and explores the role of iron supplementation in this setting. Keywords critical illness erythropoiesis iron metabolism Introduction .