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Báo cáo khoa học: "Hypocholesterolemia in sepsis and critically ill or injured patients"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hypocholesterolemia in sepsis and critically ill or injured patients. | Available online http ccforum.eom content 7 6 413 Commentary Hypocholesterolemia in sepsis and critically ill or injured patients Robert F Wilson1 Jeffrey F Barletta2 and James G Tyburski3 1 Professor of Surgery Department of Surgery Wayne State University School of Medicine Detroit Receiving Hospital Detroit Michigan USA 2Department of Pharmacology Wayne State University School of Medicine Detroit Receiving Hospital Detroit Michigan USA 3Associate Professor of Surgery Department of Surgery Wayne State University School of Medicine Detroit Receiving Hospital Detroit Michigan USA Correspondence Robert F Wilson Published online 6 October 2002 Critical Care 2003 7 413-414 DOI 10.1186 cc2390 This article is online at http ccforum.com content 7 6 413 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Hypocholesterolemia is an important observation following trauma. In a study of critically ill trauma patients mean cholesterol levels were significantly lower 119 44 mg dl than expected values 201 17 mg dl . In patients who died final cholesterol levels fell by 33 versus a 28 increase in survivors. Cholesterol levels were also adversely affected by infection or organ system dysfunction. Other studies have illustrated the clinical significance of hypocholesterolemia. Because lipoproteins can bind and neutralize lipopolysaccharide hypocholesterolemia can negatively impact outcome. New therapies directed at increasing low cholesterol levels may become important options for the treatment of sepsis. Keywords endotoxemia hypocholesterolemia hypolipidemia outcome trauma It was a pleasure to read the report from Dunham and coworkers 1 concerning the relationship between hypocholesterolemia and outcome in patients following severe trauma. Although their study involved only 28 patients these patients were severely injured Injury Severity Score 31 9 and they required at least 7 days of mechanical ventilation. Upon admission to the surgical intensive care unit