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Báo cáo khoa học: "Associations among systemic blood pressure, microalbuminuria and albuminuria in dogs affected with pituitary- and adrenal-dependent hyperadrenocorticism"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Associations among systemic blood pressure, microalbuminuria and albuminuria in dogs affected with pituitary- and adrenal-dependent hyperadrenocorticism. | Lien et al. Acta Veterinaria Scandinavica 2010 52 61 http www.actavetscand.eom content 52 1 61 AVS ACTAVETERINARIA SCANDINAVICA RESEARCH Open Access Associations among systemic blood pressure microalbuminuria and albuminuria in dogs affected with pituitary- and adrenal-dependent hyperadrenocorticism Yu-Hsin _ien1 2t Tsai-Yuan Hsiang2t Hui-Pi Huang2 Abstract Background Hypertension and proteinuria are medical complications associated with the multisystemic effects of long-term hypercortisolism in dogs with hyperadrenocorticism HAC . Methods This study investigated the relationships among adrenocorticotropic hormone ACTH -stimulation test results systemic blood pressure and microalbuminuria in clinically-healthy dogs n 100 in dogs affected with naturally occurring pituitary-dependent PDH n 40 or adrenal-dependent hyperadrenocorticism ADH n 30 . Results Mean systemic blood pressure was similar between clinically healthy dogs and dogs with HAC p 0.803 . However the incidence of hypertension was highest in dogs with ADH p 0.017 followed by dogs with PDH with the lowest levels in clinically healthy dogs p 0.019 . Presence of microalbuminuria and albuminuria in clinically healthy dogs and dogs affected with HAC was significantly different p 0.001 incidences of albuminuria followed the same pattern of hypertension highest incidence in dogs with ADH and lowest level in clinically healthy dogs but microalbuminuria showed a different pattern clinically healthy dogs had highest incidences and dogs with ADH had lowest incidence. The presence of albuminuria was not associated with blood pressure values regardless of whether dogs were clinically healthy or affected with ADH or PDH p 0.306 . Conclusions Higher incidence of hypertension and albuminuria not microalbuminuria was seen in dogs affected with HAC compared to clinically healthy dogs incidence of hypertension and albuminuria was significantly higher in dogs affected with ADH compared to PDH. However presence of albuminuria