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Báo cáo khoa học: "Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats. | Martiniaková et al. Acta Veterinaria Scandinavian 2011 53 49 http www.actavetscand.eom content 53 1 49 AVS ACTAVETERINARIA Scatand eaaria SCANDINAVICA RESEARCH Open Access Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats I 117 41 I_I Í u 1 t D r I I x 1I 2 t D I m I r r r t- 431 u DX z I .-V. 1 4 MoniKd MariinidKova Hana Chovancova Radoslav omelKa Birgit GrossKopt and Robert Toman Abstract Background Exposure to cadmium Cd is considered a risk factor for various bone diseases in humans and experimental animals. This study investigated the acute effects of Cd on femoral bone structure of adult male rats after a single intraperitoneal administration. Methods Ten 4-month-old male Wistar rats were injected intraperitoneally with a single dose of 2 mg CdCl2 Kg body weight and Killed 36 h after the Cd had been injected. Ten 4-month-old males served as a control group. Differences in body weight femoral weight femoral length and histological structure of the femur were evaluated between the two groups of rats. The unpaired Student s t-test was used for establishment of statistical significance. Results A single intraperitoneal administration of Cd had no significant effect on the body weight femoral weight or femoral length. On the other hand histological changes were significant. Rats exposed to Cd had significantly higher values of area perimeter maximum and minimum diameters of the primary osteons vascular canals and Haversian canals. In contrast a significant decrease in all variables of the secondary osteons was observed in these rats. Conclusions The results indicate that as expected a single intraperitoneal administration of 2 mg CdCl2 Kg body weight had no impact on macroscopic structure of rat s femora however it affected the size of vascular canals of primary osteons Haversian canals and secondary osteons. Background Cadmium Cd is considered a dangerous poison for humans and animals. Adverse health effects .