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Báo cáo y học: "Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension. | Available online http ccforum.eom content 5 6 355 Research article Acute hemodynamic effects of inhaled nitric oxide dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension Carmine D Vizza Giorgio Della Rocca1- Angelo Di Roma Carlo Iacoboni Federico Pierconti1- Federico Venuta Erino Rendina Giovanni Schmid Paolo Pietropaoli1 and Francesco Fedele Department of Cardiovascular and Respiratory Sciences University of Rome La Sapienza Rome Italy Department of Anesthesiology University of Rome La Sapienza Rome Italy Department of Thoracic Surgery University of Rome La Sapienza Rome Italy Correspondence Giorgio Della Rocca giorgio.dellarocca@uniroma1.it Received 13 August 2001 Revisions requested 16 August 2001 Revisions received 29 August 2001 Accepted 30 August 2001 Published 9 October 2001 Critical Care 2001 5 355-361 2001 Vizza et al licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X See Commentaries page 286 Abstract Introduction The use of low-dose dobutamine to maintain hemodynamic stability in pulmonary hypertension may have a detrimental effect on gas exchange. The aim of this study was to investigate whether inhaled nitric oxide INO dobutamine and a combination of the two have beneficial effects in patients with end-stage airway lung disease and pulmonary hypertension. Method Hemodynamic evaluation was assessed 10 min after the administration of each drug and of their combination in 28 candidates for lung transplantation. Results Administration of INO caused a reduction in mean pulmonary arterial pressure MPAP an increase in PaO2 with a significant reduction in venous admixture effect Qs Qt . Dobutamine administration caused an increase in cardiac index and MPAP with a decrease in PaO2 as a result of a higher Qs Qt. Administration of a combination of the two drugs caused an increase in the cardiac index without MPAP modification and an increase in PaO2 and Qs Qt. Conclusion Dobutamine and INO