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Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization

The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. | IFEBS Journal MINIREVIEW Function and regulation of ABCA1 - membrane meso-domain organization and reorganization Kohjiro Nagao Maiko Tomioka and Kazumitsu Ueda Institute for Integrated Cell-MaterialSciences iCeMS Kyoto University Japan Keywords ATP-binding cassette protein cholesterol homeostasis lipid raft membranes phospholipids Correspondence K. Ueda Institute for integrated Cell-MaterialSciences iCeMS Kyoto University Kyoto 606-8502 Japan Fax 81 75 753 6104 Tel 81 75 753 6124 E-mail uedak@kais.kyoto-u.ac.jp Received 17 December 2010 revised 27 February 2011 accepted 6 May 2011 doi 10.1111 j.1742-4658.2011.08170.x The ATP-binding cassette protein A1 ABCA1 mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor apolipoprotein A-I to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1 moves lipids not only between membranes but also within membranes to organize and reorganize membrane meso-domains to modulate cell proliferation and immunity. Introduction The plasma membrane is critical for the life of the cell not only as the boundary maintaining the cytosolic environment differently from the extracellular environment but also as a platform for protein assembly which converts extracellular stimuli into intracellular signals. The skin lipid barrier prevents water loss from our body lipids in the myelin sheath functions as an insulator of nerve fibers and pulmonary surfactant lipids at the air-water interface decrease alveolar surface tension. These lipids are appropriately transported in our body and within cells and their abnormal deposition causes cell death and various diseases Table 1 . Several ATP-binding cassette protein A ABCA subfamily proteins are involved in lipid transport between organs and between intracellular .