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Báo cáo y học: " Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study. | Lee et al. Arthritis Research Therapy 2011 13 R83 http arthritis-research.eom content 13 3 R83 RESEARCH ARTICLE Open Access Pain persists in DAS28 rheumatoid arthritis remission but not in ACR EULAR remission a longitudinal observational study Yvonne C Lee Jing Cui Bing Lu Michelle L Frits Christine K lannaccone Nancy A Shadick Michael E Weinblatt and Daniel H Solomon Abstract Introduction Disease remission has become a feasible goal for most rheumatoid arthritis RA patients however patient-reported symptoms such as pain may persist despite remission. We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score DAS28-CRP4 and the American College of Rheumatology European League Against Rheumatism ACR EULAR remission criteria. Methods Data were analyzed from RA patients in the Brigham Rheumatoid Arthritis Sequential Study with data at baseline and 1 year. DAS28 remission was defined as DAS28-CRP4 2.6. The ACR EULAR remission criteria included a one or more swollen joints b one or more tender joints c C-reactive protein 1 mg dl and d patient global assessment score 1. Pain severity was measured by using the pain score from the Multi-Dimensional Health Assessment Questionnaire MDHAQ . The associations between baseline clinical predictors and MDHAQ pain at baseline and 1 year were assessed by using multivariable linear regression. Results Among the 865 patients with data at baseline and 1 year 157 18.2 met DAS28-CRP4 remission criteria at both time points. Thirty-seven 4.3 met the ACR EULAR remission criteria at baseline and 1 year. The prevalence of clinically significant pain MDHAQ pain 4 at baseline ranged from 11.9 among patients meeting DAS28-CRP4 remission criteria to none among patients meeting ACR EULAR remission criteria. Patient global assessment MDHAQ function MDHAQ fatigue MDHAQ sleep and arthritis self-efficacy were significantly associated with MDHAQ pain in cross-sectional P 0.0005 and longitudinal analyses P .