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NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP)

As part of the world’s commitment towards the right to development, peace and security, gender equality, eradication of multi-dimensional poverty and sustainable human development, the GoN endorsed the Millennium Declaration in September 2000. In order to achieve the Millennium Development Goals (MDGs), the GoN has incorporated the MDGs into the strategic framework of the country’s Tenth Plan/Poverty Reduction Strategy Paper (2002/03-2006/07). This section attempts to provide a snapshot of Nepal’s achievement towards meeting its targets in relation to the MDGs and the SLTHP. The assessment is done only with respect to available information as derived from. | Notional Toxicology Program U.S. Department ofHealth and Human Services . F vl F I . tf I Center For The Evaluation Of Risks To Human Reproduction NTP NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate DIDP April 2003 NIH Publication No. 03-4485 Table of Contents Preface.i Introduction.ii NTP Brief on Di-Isodecyl Phthalate DIDP .1 References.3 Appendix I. NTP-CERHR Phthalates Expert Panel Preface.I-1 Expert Panel.I-2 Appendix II. Phthalates Expert Panel Report on DIDP Preface.II-i Chemistry Usage and Exposure.II-1 General Toxicological and Biological Parameters .II-4 Developmental Toxicity Data.II-10 Reproductive Toxicity.II-14 Data Summary Integration.II-17 References.II-31 Tables .II-35 Appendix III. Public Comments on the Phthalates Expert Panel Reports AdvaMed.III-1 American Chemistry Council 12-7-2000 .III-5 American Chemistry Council 12-11-2000 .III-7 American Chemistry Council 4-13-2001 .III-58 Discovery Medical Inc.III-66 Environmental Working Group 11-3-2000 .III-67 Environmental Working Group 12-8-2000 .III-69 William Faber.III-71 Healthy Environments Product Safety Branch.III-81 Health Care Without Harm.III-83 Beverly Smith.III-87 Swedish Chemical Inspection Agency.III-88 Preface The National Toxicology Program NTP established the NTP Center for the Evaluation of Risks to Human Reproduction CERHR in 1998. The CERHR is a publicly accessible resource for information about adverse reproductive and or developmental health effects associated with exposure to environmental and or occupational chemicals. The CERHR is located at the National Institute of Environmental Health Sciences NIEHS of the National Institutes of Health and Dr. Michael Shelby is the director.1 The CERHR broadly solicits nominations of chemicals for evaluation from the public and private sectors. The CERHR follows a formal process for review and evaluation of nominated chemicals that includes multiple opportunities for public comment.