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báo cáo hóa học:" The reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a trial population"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : The reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a trial population | BioMed Central Health and Quality of Life Outcomes Research Open Access The reliability validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire RLSQoL in a trial population Linda Abetz 1 Robert Arbuckle1 Richard P Allen2 Elena Mavraki3 and Jeffrey Kirsch3 Address 1Mapi Values Adelphi Mill Bollington Macclesfield SK10 5JB UK 2Johns Hopkins Bayview Medical Center Neurology and Sleep Medicine Asthma and Allergy Building 1B46b 5501 Hopkins Bayview Circle Baltimore MD 21224 USA and 3GlaxoSmithKline Greenford Road Greenford Middlesex UB6 0HE UK Email Linda Abetz - linda.abetz@mapivalues.com Robert Arbuckle - rob.arbuckle@mapivalues.com Richard P Allen - richardJHU@aol.com Elena Mavraki - elena.2.mavraki@gsk.com Jeffrey Kirsch - jeff.kirsch-1@gsk.com Corresponding author Published 05 December 2005 Received 24 June 2005 Health and Quality of Life Outcomes 2005 3 79 doi l0.ll 86 1477-7525-3-79 Accepted 05 December 2005 This article is available from http www.hqlo.cOm content 3 1 79 2005 Abetz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The aim of this study was to determine the reliability validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire RLSQoL in a clinical trial setting. Methods Two matching placebo-controlled multinational studies assessing the effectiveness and safety of ropinirole for treating moderate-to-severe Restless Legs Syndrome RLS formed the basis of this psychometric assessment. Validity and reliability were assessed using baseline data. Responsiveness was determined using longitudinal data collected at baseline and l2 weeks. Results A total of 547 subjects formed the baseline validation population 5l9 were used for .