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báo cáo khoa học: "A dramatic, objective antiandrogen withdrawal response: case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature | BioMed Central Journal of Hematology Oncology Open Access Case report A dramatic objective antiandrogen withdrawal response case report and review of the literature Yiu-Keung Lau1 Manpreet K Chadha2 Alan Litwin3 and Donald LTrump 2 Address 1Hematology Oncology Department of Medicine West Virginia University West Virginia USA 2Department of Medicine Roswell Park Cancer Institute Elm and Carlton Streets Buffalo NY USA and 3Department of Radiology Roswell Park Cancer Institute Elm and Carlton Streets Buffalo NY USA Email Yiu-Keung Lau - jlau@hsc.wvu.edu Manpreet K Chadha - manpreet.chadha@roswellpark.org Alan Litwin - alan.litwin@roswellpark.org Donald LTrump - donald.trump@roswellpark.org Corresponding author Published 5 November 2008 Received 24 July 2008 Journal of Hematology Oncology 2008 1 21 doi 10.1186 1756-8722-1-21 Accepted 5 November 2008 This article is available from http www.jhoonline.org content 1 1 21 2008 Lau et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Antiandrogen withdrawal response is an increasingly recognized entity in patients with metastatic prostate cancer. To our knowledge there have been no reports describing a durable radiologic improvement along with prostate-specific antigen PSA with discontinuation of the antiandrogen agent bicalutamide. We report a case in which a dramatic decline of serum PSA levels associated with a dramatic improvement in radiologic disease was achieved with bicalutamide discontinuation. Background Cancer of the prostate is the most prevalent cancer of American men 1 . At the time of diagnosis almost 50 of the patients have disease that extends beyond the prostate gland. .