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báo cáo khoa học: "A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China"
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China | Journal of Hematology Oncology BioMed Central Open Access Short report A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia a single center experience from China Jianmin Wang t Shuqing Luf Jianmin Yang Xianmin Song Li Chen Chongmei Huang Jun Hou and Weiping Zhang Address Department of Hematology Changhai Hospital Second Military Medical University Shanghai PR China Email Jianmin Wang - jmwang@medmail.com.cn Shuqing Lu - lsq7219@sohu.com Jianmin Yang - yang3401@yahoo.com Xianmin Song - shongxm@gmail.com Li Chen - yuhe0628@yahoo.com.cn Chongmei Huang - huangchongmei@yahoo.cn Jun Hou - houjun@163.com Weiping Zhang - zhangwp@medmail.com Corresponding author fEqual contributors Published 30 July 2009 Received 1 June 2009 Journal of Hematology Oncology 2009 2 32 doi 10.1186 1756-8722-2-32 Accepted 30 July 2009 This article is available from http www.jhoonline.Org content 2 1 32 2009 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background and purpose The response to remission induction in elderly patients with acute myeloid leukemia AML remains poor. The purpose of this paper is to evaluate the efficacy and toxicity of a plant alkaloid homoharringtonine in combination with cytarabine as an induction therapy for AML in elderly patients 60 years . Results Twenty-three patients were treated with the HA regimen consisting of homoharringtonine 2 mg m2 day for 7 days and cytarabine Ara-C 100 mg m2 day for 7 days . The overall response rate was 56.5 with complete remission CR rate of 39.1 and partial remission of 17.4 . There was no early death in this cohort of patients. The estimated median overall survival OS time of all patients was 12.0 3.0 months. The .