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Báo cáo y học: "Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients. | Available online http arthritis-research.eom content 9 3 R60 Research article Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients Reinout Stoop1 Dirk Albrecht2 Christoph Gaissmaier2 Jurgen Fritz2 Tino Felka3 Maximilian Rudert4 and Wilhelm K Aicher3 1NMI Natural and Medical Sciences Institute at the University of Tubingen MarkwiesenstraBe 72770 Reutlingen Germany 2BG Center for Traumatology SchnarrenbergstraBe 72076 Tubingen Germany 3Center for Medical Research Department of Orthopaedic Surgery University of Tubingen WaldhornlestraBe 72072 Tubingen Germany 4Department of Orthopaedic Surgery Technische Universitat Munchen Ismaninger Str. 81 675 Munich Germany Corresponding author Wilhelm K Aicher aicher@uni-tuebingen.de Received 13 Sep 2006 Revisions requested 18 Oct 2006 Revisions received 23 Apr 2007 Accepted 27 Jun 2007 Published 27 Jun 2007 Arthritis Research Therapy 2007 9 R60 doi 10.1186 ar2218 This article is online at http arthritis-research.com content 9 3 R60 2007 Stoop et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Currently autologous chondrocyte transplantation ACT is used to treat traumatic cartilage damage or osteochondrosis dissecans but not degenerative arthritis. Since substantial refinements in the isolation expansion and transplantation of chondrocytes have been made in recent years the treatment of early stage osteoarthritic lesions using ACT might now be feasible. In this study we determined the gene expression patterns of osteoarthritic OA chondrocytes ex vivo after primary culture and subculture and compared these with healthy chondrocytes ex vivo and with articular chondrocytes .

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