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Báo cáo khoa học: " Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis"
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis. | Radiation Oncology BioMed Central Research Radiation-induced skin injury in the animal model of scleroderma implications for post-radiotherapy fibrosis Sanath Kumar 1 Andrew Kolozsvary1 Robert Kohl1 Mei Lu2 Stephen Brown1 and Jae Ho Kim1 Address Department of Radiation Oncology Henry Ford Health System Detroit MI USA and 2Department of Biostatistics and Research Epidemiology Henry Ford Health System Detroit MI USA Email Sanath Kumar - skumar4@hfhs.org Andrew Kolozsvary-akolozs1@hfhs.org Robert Kohl - rkohl1@hfhs.org Mei Lu - mlu1@hfhs.org Stephen Brown - sbrown1@hfhs.org Jae Ho Kim - jkim1@hfhs.org Corresponding author Open Access Published 24 November 2008 Received 28 July 2008 Accepted 24 November 2008 Radiation Oncology 2008 3 40 doi 10.1186 1748-717X-3-40 This article is available from http www.ro-journal.com content 3 1 40 2008 Kumar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Radiation therapy is generally contraindicated for cancer patients with collagen vascular diseases CVD such as scleroderma due to an increased risk of fibrosis. The tight skin TSK mouse has skin which in some respects mimics that of patients with scleroderma. The skin radiation response of TSK mice has not been previously reported. If TSK mice are shown to have radiation sensitive skin they may prove to be a useful model to examine the mechanisms underlying skin radiation injury protection mitigation and treatment. Methods The hind limbs of TSK and parental control C57BL 6 mice received a radiation exposure sufficient to cause approximately the same level of acute injury. Endpoints included skin damage scored using a non-linear semi-quantitative scale and tissue fibrosis assessed by measuring passive leg extension. .