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Báo cáo khoa học: "Semi-robotic 6 degree of freedom positioning for intracranial high precision radiotherapy; first phantom and clinical results"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Semi-robotic 6 degree of freedom positioning for intracranial high precision radiotherapy; first phantom and clinical results. | Wilbert etal. Radiation Oncology 2010 5 42 http www.ro-journal.eom content 5 1 42 RADIATION ONCOLOGY RESEARCH Open Access Sem -robotic 6 degree of freedom positioning for intracranial high precision radiotherapy first phantom and clinical results Jurgen Wilbert 1 Matthias Guckenberger Bulent Polat Otto Sauer Michael Vogele Michael Flentje and Reinhart A Sweeney Abstract Background To introduce a novel method of patient positioning for high precision intracranial radiotherapy. Methods An infrared IR -array reproducibly attached to the patient via a vacuum-mouthpiece vMP and connected to the table via a 6 degree-of-freedom DoF mechanical arm serves as positioning and fixation system. After IR-based manual prepositioning to rough treatment position and fixation of the mechanical arm a cone-beam CT CBCT is performed. A robotic 6 DoF treatment couch HexaPOD then automatically corrects all remaining translations and rotations. This absolute position of infrared markers at the first fraction acts as reference for the following fractions where patients are manually prepositioned to within 2 mm and 2 of this IR reference position prior to final HexaPOD-based correction consequently CBCT imaging is only required once at the first treatment fraction. The preclinical feasibility and attainable repositioning accuracy of this method was evaluated on a phantom and human volunteers as was the clinical efficacy on 7 pilot study patients. Results Phantom and volunteer manual IR-based prepositioning to within 2 mm and 2 in 6DoF was possible within a mean SD of 90 31 and 56 22 seconds respectively. Mean phantom translational and rotational precision after 6 DoF corrections by the HexaPOD was 0.2 0.2 mm and 0.7 0.8 respectively. For the actual patient collective the mean 3D vector for inter-treatment repositioning accuracy n 102 was 1.6 0.8 mm while intra-fraction movement n 110 was 0.6 0.4 mm. Conclusions This novel semi-automatic 6DoF IR-based system has been shown to compare .