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Báo cáo y học: "What can chronic arthritis pain teach about developing new analgesic drugs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:What can chronic arthritis pain teach about developing new analgesic drugs? | Available online http arthritis-research.eom content 6 6 279 Commentary What can chronic arthritis pain teach about developing new analgesic drugs James Witter1 and Raymond A Dionne2 1 Center for Drug Evaluation Research CDER FDA Rockville Maryland USA 2National Institute of Dental and Craniofacial Research NIH Bethesda Maryland USA Corresponding author Raymond Dionne raymond.dionne@nih.gov Published 15 October 2004 Arthritis Res Ther 2004 6 279-281 DOI 10.1186 ar1450 2004 BioMed Central Ltd Abstract Chronic pain remains an important public health need with greater impact on the US economy than most other chronic conditions. Current pain management is largely limited to opioids and non-steroidal anti-inflammatory drugs indicating a gap in the translation of new knowledge to the development of improved pain treatments. Strategies suggested include the re-evaluation of current drug screening methods a recognition that molecular-genetic events occurring acutely contribute to the development of pain chronicity the validation of analgesic targets in the intended patient population consideration of the unique genetic profile that varies between individuals and the introduction of individual response measures to improve the capture of outcomes in clinical trials. Keywords analgesics chronic pain drug development individual responses pain mechanisms Despite the availability of opium and willow-bark derivatives for centuries chronic pain remains an important unmet public health need. Although definitive epidemiologic data are lacking millions of Americans 1 live with serious malignant and non-malignant chronic pain this pain subsequently affects almost every aspect of their lives. In fact a recent study suggests that chronic pain has a greater impact about US 100 billion annually on the US economy in health insurance lost wages and reduced productivity than any other chronic condition including heart disease hypertension and diabetes 2 . Unmet needs for analgesia are also .