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Báo cáo khoa học: "A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy | El Mesbahi et al. World Journal of Surgical Oncology 2010 8 77 http www.wjso.eom content 8 1 77 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy 1 1 1 2 3 4 Omar El Mesbahi Samia Arifi Zineb Benbrahim Abdelhalim El Ibrahimi Fouad Kettani Amal Bennani Afaf Amarti4 My Youssef Alaoui Lamrani5 Siham Tizniti5 Abdelmajid El Mrini2 Abstract Fibrosarcomas FS of bone are a rare malignancy accounting for less than 5 of all primary malignant bone neoplasms. Diagnosis and treatment approaches of this entity are complex and require a skilled and experienced multidisciplinary team. Authors report their experience with a case of FS of humerus showing a pathologic complete response to neoadjuvant chemotherapy based on adriamycin cisplatin and ifosfamid. This approach allowed limb-sparing surgery with an excellent functional and psychological result. Background Fibrosarcomas FS of bone represent 5 of all primary bone sarcomas 1 2 . It occurs most frequently in the middle age 1 and affects men and women with equal frequency. In addition it affects most commonly the long bones. The tumor may be either central 68 or cortical 31 1 . Fibrosarcomas can arises as a primary lesions or secondary to fibrous dysplasia to Paget s disease to bone infarcts to osteomyelitis or to postirradiation of bone and giant cell tumors GCT 3 4 . Histologically tumors are characterized by interlacing bundles of collagen fibers without any osteoid or cartilage production 1 . Differential diagnosis includes fibroblastic osteosarcoma and malignant fibrous histiocytoma MFH 5 . Surgery is the standard treatment for fibrosarcoma of bone 1 . Amputation was the primary method of therapy yielding the best curative results 1 . However by combining advanced bone imaging techniques with surgical techniques implant development and neo-adjuvant therapy limb-sparing .