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báo cáo khoa học: "Clinicopathologic features of incidental prostatic adenocarcinoma in radical cystoprostatectomy specimens"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinicopathologic features of incidental prostatic adenocarcinoma in radical cystoprostatectomy specimens | Aytac and Vuruskan World Journal of Surgical Oncology 2011 9 81 http www.wjso.eom content 9 1 81 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Clinicopathologic features of incidental prostatic adenocarcinoma in radical cystoprostatectomy specimens Berna Aytac1 and Hakan Vuruskan2 Abstract Background The aim of this study is to review all features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer. Methods The medical charts of 300 male patients who underwent radical cystoprostatectomy for bladder cancer between 1997 and 2005 were retrospectively reviewed. The mean age of the patients was 62 range 51-75 years. Results Prostate adenocarcinoma was present in 60 20 of 300 specimens. All were acinar adenocarcinoma. Of these 40 66.7 were located in peripheral zone 20 33.3 had pT2a tumor 12 20 had pT2b tumor 22 36.7 had pT2c and 6 10 had pT3a tumor. Gleason score was 6 or less in 48 80 patients. Surgical margins were negative in 54 90 patients and tumor volume was less than 0.5 cc in 23 38.3 patients. Of the 60 incidentally detected cases of prostate adenocarcinoma 40 66.7 were considered clinically significant. Conclusion Incidentally detected prostate adenocarcinoma is frequently observed in radical cystoprostatectomy specimens. The majority are clinically significant. Keywords Bladder cancer cystoprostatectomy incidental prostate cancer Background Prostate adenocarcinoma PCa is the most common visceral malignancy in the male population and the second leading cause of death in men 1 . It can be found incidentally when the prostate is removed during radical cystoprostatectomy RCP for bladder cancer and latently at autopsy or clinically diagnosed by physical examination laboratory tests and symptoms 2 3 . In autopsy series incidental prostate cancer is found in 30 of men in their fifth decade and that rate increases to as high as 90 in men aged older than 90 years 4 . The frequency of PCa