Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritis. | Arthritis Research Therapy Vol 5 No 2 Amin Commentary A need for a whole-istic functional genomics approach in complex human diseases arthritis Ashok R Amin Hospital for Joint Diseases NYU School of Medicine New York USA Correspondence Ashok R Amin e-mail ashok.amin@msnyuhealth.org Received 22 November 2002 Accepted 8 January 2003 Published 28 January 2003 Arthritis Res Ther 2003 5 76-79 DOI 10.1186 ar626 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Genomic tools such as gene protein chips single nucleotide polymorphism and haplotype analyses are empowering us to generate staggering amounts of correlative data from human animal genetics and from normal and disease-affected tissues obtained from complex diseases such as arthritis. These tools are transforming molecular biology into a data rich science with subjects with an -omic suffix. These disciplines have to converge and integrate at a systemic level to examine the structure and dynamics of cellular and organismal function functionomics simultaneously using a multidimensional approach for cells tissues organs rodents and Zebra fish models which intertwines various approaches and readouts to study the development and homeostasis of a system. In summary the postgenomic era of functionomics will facilitate narrowing the bridge between correlative data and causative data thus integrating intercoms of interacting and interdependent disciplines and forming a unified whole. Keywords arthritis genomics inflammation proteomics Introduction Arthritis is a complex disease with an unknown etiology. Some of the common underlining symptoms include inflammation dysfunction of joints due to destruction of cartilage and soft tissue. Based on the clinical symptoms arthritis can be classified as osteoarthritis OA rheumatoid arthritis synovial lipomatosis avascular necrosis crystal deposition disease Goud and other diseases 1 . A major challenge we face in the postgenomic era is the characterization .