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Báo cáo y học: "Predicting hospital admission and discharge with symptom or function scores in patients with schizophrenia: pooled analysis of a clinical trial extension"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Predicting hospital admission and discharge with symptom or function scores in patients with schizophrenia: pooled analysis of a clinical trial extension. | Kozma et al. Annals of General Psychiatry 2010 9 24 http www.annals-general-psychiatry.eom content 9 1 24 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Predicting hospital admission and discharge with symptom or function scores in patients with schizophrenia pooled analysis of a clinical trial extension Chris M Kozma 1 Riad G Dirani2 Carla M Canuso2 and Lian Mao2 Abstract Background The purpose of this analysis was to evaluate relationships between hospital admission or discharge and scores for symptom or functioning in patients with schizophrenia. Methods Data were from three 52-week open-label extensions of the double-blind pivotal trials of paliperidone extended-release ER . Symptoms and patient function were measured every 4 weeks using the Personal and Social Performance PSP scale and the Positive and Negative Syndrome Scale PANSS . The intent-to-treat analysis set was defined as open-label patients who had at least one post-baseline PSP and PANSS measurement. Time until first hospitalization was evaluated using the Cox proportional hazard model with categorical time-dependent measures for the PSP 1 to 30 31 to 70 71 to 100 or PANSS 75 75 to 95 95 as well as age gender schizophrenia duration and country. Similar analyses were performed for time to discharge. Results Of the 1 077 enrolled patients 1 028 95.5 met study criteria of these 382 37.2 were hospitalized at open-label baseline. Compared with patients with PSP 71 group the hazard for new hospitalization was 8.351 times greater P 0.0001 for patients with the poorest functioning PSP 1 to 30 and 1.977 times greater P 0.0295 for patients with PSP of 31-70 compared to the 71 group. The hazard for new hospitalization was 5.457 times greater P 0.0001 for patients PANSS 95 and 2.316 times greater P 0.0027 for the 75 to 95 group compared with the 75 group. For patients hospitalized at baseline the PANSS 95 patients had a discharge hazard that was 0.456 times lower than for the 75 patients P 0.0001 . .