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CASARETT AND DOULL’S TOXICOLOGY THE BASIC SCIENCE OF POISONS

The seventh edition of Casarett and Doull’s Toxicology: The Basic Science of Poisons, as the previous six, is meant to serve primarily as a text for, or an adjunct to, graduate courses in toxicology. Because the six previous editions have been widely used in courses in environmental health and related areas, an attempt has been made to maintain those characteristics that make it useful to scientists from other disciplines. This edition will again provide information on the many facets of toxicology, especially the principles, concepts, and modes of thoughts that are the foundation of the discipline. Mechanisms of toxicity are emphasized. Research toxicologists will find this book an excellent reference. | SEVENTH EDITION Casarett Doull s Toxicology -pl n__ Tr in- - o I he Basic Science of Poisons Casarett and Doull s toxicology The Basic Science of Poisons What is there that is not poison All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison. Paracelsus 1493-1541 NOTICE Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However in view of the possibility of human error or changes in medical sciences neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used .