Đang chuẩn bị liên kết để tải về tài liệu:
INFLAMMATORY BOWEL DISEASE - PART 8

Viêm loét đại tràng (UC) và bệnh Crohn (CD) có liên quan với một loạt các biểu hiện extraintestinal (EIM) thường làm cho quản lý của họ khó khăn và là nguyên nhân đáng kể tỷ lệ mắc và tử vong (Hình 1). Một EIM có thể xảy ra trước khi, đồng thời với, hoặc sau khi | 13 Extraintestinal Manifestations of Inflamamtory Bowel Disease Elena Ricart MD and William J. Sandborn MD Contents Introduction Pathogenesis Musculoskeletal Manifestations Dermatologic Manifestations Hepatobiliary Manifestations Ocular Manifestations Renal Urologic manifestations Pancreatic Manifestations Pulmonary Manifestations Cardiac Manifestations Neurologic Manifestations Hematologic Manifestations Metabolic and Endocrine Manifestations Summary References INTRODUCTION Ulcerative colitis UC and Crohn s disease CD are associated with a wide variety of extraintestinal manifestations EIM that often make their management difficult and are significant causes of morbidity and mortality Fig. 1 . An EIm can occur before concomitant with or after From Clinical Gastroenterology Inflammatory Bowel Disease Diagnosis and Therapeutics Edited by R. D. Cohen Humana Press Inc. Totowa NJ 257 258 Ricart and Sandborn Skin and mucosae Aphthous stomatitis Cheilitis Peristomatitis vegetans Dermatologic Erythema nodosum Pyoderma gangrenosum Metastatic Crohn s disease Psoriasis Epidermolysis bullosa acquisita Sweet s syndrome Perianal disease Polyarteritis nodosa Acrodermatitis enteropathica Ocular Uveitis iritis Episcleritis Chorioretinitis Retinal vascular disease Cardiac Pleuropericarditis Cardiomyopathy Myocarditis Endocarditis Musculoskeletal Colitic arthritis Sacroiliitis Ankylosing spondylitis Hypertrophic osteoarthropathy Osteoporosis osteomalacia Granulomatous synovitis Rheumatoid arthritis Osteonecrosis Steroid-induced myopathy Hematologic Iron deficiency anemia Folate deficiency Vitamin B12 deficiency Autoimmune hemolytic anemia Anemia of chronic disease Coagulation abnormalities Thrombocytosis thrombocytopenia Hepatobiliary and pancreatic Primary sclerosing cholangitis Steatosis Cholelithiasis Cholangiocarcinoma Autoimmune hepatitis Pancreatitis Pancreatic insufficiency Renal and genitourinary Nephrolithiasis Obstructive hydronephrosis Enteroveslcal fistulae .