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FOR ORGANIC CHEMICALS IN WATER (latest version 04/01)

In some countries and regions regulations have been introduced with the aim of restricting the use of hazardous substances in these products, and the management of e-waste at the products end of life. However, no such regulations exist in many of the countries in which where products are manufactured, used and disposed of. Furthermore, even where they apply, regulations do not control all hazardous chemicals and materials that are used in newly manufactured products, nor fully address the management of e- waste. Even in the EU, where some of the more stringent regulations apply, as much as 75% of generated e-waste is unaccounted for. There is evidence. | FOR ORGANIC CHEMICALS IN WATER latest version 04 01 Worksheet to Calculate Dermal Absorption of Organic Chemicals from Aqueous Media latest version 04 01 Enter the Following Exposure Conditions for site specific conditions change values in Cells I8-I18 The default exposure conditions used in this spreadsheet assume exposure duration for carcinogenic effects of chemicals in water through showering Concentration mg L L 1000 cm3 Input site specific concentrations in Column marked Conc Area exposed cm2 Event time hr event Event frequency events day Exposure frequency days year Exposure duration years for carcinogenic effects ED 30 years used in this spreadsheet for noncarcinogenic effects ED 9 years Body weight kg Averaging time days for carcinogenic effects AT 70 years 25 550 days for noncarcinogenic effects AT ED in days Skin thickness assumed to be 10 um Conc SA t_event EV EF ED BW AT lsc 1E-03 mg cm3 default value for purpose of illustration 1 mg L 1 p 1 ug cm3 1000 ppb 18000 cm2 0.58 hr event 35 minutes event 1.0 event day 350.0 days yr 30.0 years 70.0 kg 25550 days 1.00E-03 cm Default conditions for screening purposes Compare Dermal to Drinking Adults showering for 35 minutes day compared to drinking 2L water day Dermal mg day DA_event A EV Drinking mg day Conc IR ABSIG IR ABSGI 2000 cm3 day L day 1000 cm3 L 1.0 assumed 100 GI absorption IR Ingestion rate of drinking water ABSIG Absorption fraction in GI tract Refer to Appendix A for equations to evaluate DA_event and DAD Compare Dermal to Total dose exposed during adult showering assuming 5 gal min of water flow rate Total dose mg day Q T_event EV Q Shower flow rate 5-15 gal min here using 5 gal min Q 1135500.0 cm3 hr gal min 3.785 gal l 60 min hr 1000 cm3 hr outside of the Effective Prediction Domain EPD determined by the Flynn s measured Kp data as evaluated using MLAB Civilized Software Bethesda MD 95 LCI and UCI are evaluated using STATA halogenated chemicals. Note 1 FOR ORGANIC CHEMICALS IN WATER latest .