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báo cáo hóa học: " Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines"
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines | journal of occupational medicine AND TOXICOLOGY Cell death Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines Gasnier et al. Gasnier et al. Journal of Occupational Medicine and Toxicology 2010 5 29 http www.occup-med.com content 5 1 29 27 October 2010 BioMed Central Gasnier et al. Journal of Occupational Medicine and Toxicology 2010 5 29 http www.occup-med.eom content 5 1 29 JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines z- I f 1.2 1.2 1.2 -I- . 1 3 3 Céline Gasnier Nora Benachour Emilie Clair Carine Travert Frédéric Langlois Claire Laurant Cécile Decroix-Laporte3 Gilles-Eric Séralini1 2 Abstract Background Worldwide used pesticides containing different adjuvants like Roundup formulations which are glyphosate-based herbicides can provoke some in vivo toxicity and in human cells. These pesticides are commonly found in the environment surface waters and as food residues of Roundup tolerant genetically modified plants. In order to know their effects on cells from liver a major detoxification organ we have studied their mechanism of action and possible protection by precise medicinal plant extracts called Dig1. Methods The cytotoxicity pathways of four formulations of glyphosate-based herbicides were studied using human hepatic cell lines HepG2 and Hep3B known models to study xenobiotic effects. We monitored mitochondrial succinate dehydrogenase activity and caspases 3 7 for cell mortality and protection by Dig1 as well as cytochromes P450 1A1 1A2 3A4 and 2C9 and glutathione-S-transferase to approach the mechanism of actions. Results All the four Roundup formulations provoke liver cell death with adjuvants having stronger effects than glyphosate alone. Hep3B are 3-5 times more sensitive over 48 h. Caspases 3 7 are greatly activated in HepG2 by Roundup at non-cytotoxic levels and some apoptosis induction