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Applying Preventive Genomic Medicine in Clinical Practice

Fifteen consecutive recreational athletes (12 men and 3 women; mean age, 44.3 ! 7.0 years) with the diagnosis of Achilles tendinosis and a long duration of symptoms (18.3 months; range, 3 to 100) had pain during running and had tried conventional treatment (rest, nonsteroidal antiin- flammatory drugs, changes of shoes or orthoses, physical therapy, and ordinary training programs) with no effect on the Achilles tendon pain. This group of patients was contacted during the years 1995 to 1996 and selected for preoperative heavy-load eccentric calf muscle training. A control group of 15 consecutive recreational athletes (11 men and 4 women; mean age, 39.6 ! 7.9 years) with the same diagnosis and a. | ApplyingPreventive Genomic Medicine in Clinical Practice Navigenics is committed to providing genetic risk information that is fully vetted transparent and understandable.The results of our service allow physicians to implement probabilistic pre-symptomatic genetic risk assessment so that behavior modification screening and early detection can be offered to patients in a personalized manner. The goal of this document is to provide sufficient background on our service to enable you to make preventive genomic medicine and pharmacogenomics a reality in your practice. The document is organized in two sections and addresses the following key points Section I Adding genetic analysis to your clinical practice Genetic analysis is another tool in clinical decision making Individual genetic risk factors have effects equal to and often surpassing those of environmental risk factors and family history Combining genetic risk factors can identify individuals with more than ten-fold relative risk of disease compared to the genetic risk in the general population Identifying specific genetic variants can inform medication selection Certain types of patients may derive particular benefit from the service Genetic Counselors give personalized attention to you and your patient Section 2 The scientific foundation of our service Overview of human genome and variation Traditional genetic testing is indication-specific and applicable to a small number of individuals New generation of genetic testing leverages common genetic variants and is applicable to a large number of individuals Strict curation criteria of the genetic risk factors ensures scientific rigor Risk model based on genetic information provides discriminatory power to assess predisposition to disease Navigenics Inc. I Section I Adding genetic testing to your clinical practice The movement towards personalized medicine and prevention in healthcare According to the Office of the Surgeon General seven of ten Americans die each .