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Báo cáo khoa học: "Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens | J. Vet. Sci. 2005 6 3 197-200 JOURNAL OF Veterinary Science Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens M. Singh1 c. Varshneya1 R.s. Telang1 A.K. Srivastava2 Department of Pharmacology and Toxicology College of Veterinary Animal Sciences CSK Himachal Pradesh Agricultural University Palampur-176 062 Himachal Pradesh India 2Faculty of Veterinary and Animal Sciences Sher-e-Kashmir University of Agricultural Science Technology R. s. Pura Jammu-181102 India The pharmacokinetic profile of orally administered oxytetracycline 10 mg kg body weight was studied 7 days post oral treatment of Piper longum 15 mg equivalent kg in White Leghorn hens 2-2.8 kg . On the day 8 oxytetracycline OTC was administered orally and blood samples were collected from the wing vein in heparinised vials for plasma separation at 0 pre-treatment 15 30 60 120 240 360 480 and 600 minutes post OTC administration. Plasma OTC concentrations were determined by microbial assay technique using Bacillus cereus var. mycoides ATCC 11778 as test organism. The plasma levels of OTC against time were adequately described by one compartment open model. The pharmacokinetic data revealed that p. longum treated animals had significantly higher area under curve AUC area under the first moment of plasma drug concentration-time curve AUMC and mean residential time MRT . Prior treatment of p. long tun significantly reduced elimination rate constant P and increased elimination half fife tK i . The total body clearance C1B reduced by 21 whereas total duration of pharmacological effect tj increased by 29 . The treatment with P. long tun reduced loading and maintenance dose by 33.3 and 39 respectively. Keywords oral administration oxytetracycline pharmacokinetics Piper longurn white Leghorn Introduction Oxytetracycline has wide scope in the treatment of various bacterial rickettsial and mycoplasmal infections of poultry and other avian species. Notwithstanding its .