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Báo cáo khoa hoc:" Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption | Genet. Sel. Evol. 32 2000 205-216 INRA EDP Sciences 205 Original article Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption Sandrine LAGARRIGUEa Stephanie DAVALa Andre BORDASb Madeleine DOUAIREa aLaboratoire de génétique animale Institut national de la recherche agronomique Ecole nationale supérieure agronomique de Rennes 65 rue de Saint-Brieuc 35042 Rennes Cedex France bLaboratoire de génétique factorielle Institut national de la recherche agronomique 78352 Jouy-en-Josas Cedex France Received 13 September 1999 accepted 6 December 1999 Abstract - Two Rhode Island Red egg-laying lines have been divergently selected on residual food intake low intake R line high intake R line for 19 generations. In addition to direct response correlated responses have altered several other traits such as carcass adiposity and lipid contents of several tissues the R animals being leaner than the R ones. In a search for the biological origin of the differences observed in fat deposit the hepatic mRNA amounts of genes involved in lipid metabolism were investigated. No difference was found between lines for mRNA levels of ATP citrate-lyase acetyl-CoA carboxylase fatty acid synthase malic enzyme and CCAAT enhancer binding protein a a transcription factor acting on several lipogenesis genes. The genes coding for stearoyl-CoA desaturase and apolipoprotein A1 displayed significantly lower mRNA levels in the R cockerels compared to the R . All together these mRNA levels explained 40 of the overall variability of abdominal adipose tissue weight suggesting an important role of both genes in the fatness variability. laying fowl food efficiency fatness mRNA liver Résumé Expression hépatique de genes de la lipogénèse chez des lignées di-vergentes de poules pondeuses sélectionnées sur la consommation alimentaire résiduelle. Deux lignees de poules pondeuses Rhode Island Red ont été sélectionnées de facon divergente sur la .