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Obstructive lung disease in children after allogeneic bone marrow transplantation

HFMD occurs mainly in children under 10 years old, but may also occur in adults too. Everyone is at risk of infection, but not everyone who is infected becomes ill. Infants, children, and adolescents are more likely to be susceptible to infection and illness from these viruses, because they are less likely than adults to have antibodies and be immune from previous exposures to them. Infection results in immunity to the specific virus, but a second episode may occur following infection with a different virus belonging to the enterovirus group. . | From bloodjoumal.hematologylibrary.org by guest on December 8 2012. For personal use only. blood 1994 84 3212-3220 Obstructive lung disease in children after allogeneic bone marrow transplantation KR Schultz GJ Green D Wensley MA Sargent JF Magee JJ Spinelli S Pritchard JH Davis PC Rogers and KW Chan Information about reproducing this article in parts or in its entirety may be found online at http bloodjournal.hematoiogylibrary.org site misc rights.xhtml repub_requests Information about ordering reprints may be found online at http bloodjournal.hematologylibrary.org site misc rights.xhtml reprints Information about subscriptions and ASH membership may be found online at http bloodjournal.hematologylibrary.org site subscriptions index.xhtml Blood print ISSN 0006-4971 online ISSN 1528-0020 is published weekly by the American Society of Hematology 2021 L St NW Suite 900 Washington DC 20036. Copyright 2011 by The American Society of Hematology all rights reserved. From bloodjoumal.hematologylibrary.org by guest on December 8 2012. For personal use only. Obstructive Lung Disease in Children After Allogeneic Bone Marrow Transplantation By Kirk R. Schultz Gordon J. Green David Wensley Michael A. Sargent J.F. Magee John J. Spinelli Sheila Pritchard Jeffrey H. Davis Paul C.J. Rogers Ka Wah Chan and Gordon L. Phillips Obstructive lung disease OLD has been described as a significant complication after allogeneic bone marrow transplantation BMT . The incidence of OLD in adults appears to be low 3 but there is little data for children. We analyzed 89 consecutive pediatric allogeneic BMTs 21.5 years post-BMT performed at British Columbia s Children s Hospital from 1980 to 1992 for evidence of OLD. Diagnosis of OLD was based on clinical findings nonproductive cough wheezing and dyspnea with no evidence of infection pulmonary function tests FEV 80 and FEF25.75 60 predicted lung biopsy and computed tomography scan. Sixty-seven of the 89 children evaluated survived 290 days and were