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báo cáo hóa học:" Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways | Journal of Translational Medicine BioMed Central Research Proteomic characterization of HIV-modulated membrane receptors kinases and signaling proteins involved in novel angiogenic pathways Suraiya Rasheed Jasper S Yan Adil Hussain and Bruce Lai Address Laboratory of Viral Oncology and Proteomics Research Department of Pathology Keck School of Medicine University of Southern California 1840 N Soto St Los Angeles CA 90032-3626 USA Email Suraiya Rasheed - srasheed@usc.edu Jasper S Yan - Jasper.S.Yan@rice.edu Adil Hussain - ahussain@uci.edu Bruce Lai - bpl@duke.edu Corresponding author Open Access Published 27 August 2009 Received I April 2009 Journal of Translational Medicine 2009 7 75 doi 10.1186 1479-5876-7-75 Accepted 27 August 2009 This article is available from http www.translational-medicine.cOm content 7 1 75 2009 Rasheed et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Kaposi s sarcoma KS hemangioma and other angioproliferative diseases are highly prevalent in HIV-infected individuals. While KS is etiologically linked to the human herpesvirus-8 HHV8 infection HIV-patients without HHV-8 and those infected with unrelated viruses also develop angiopathies. Further HIV-Tat can activate protein-tyrosine-kinase PTK-activity of the vascular endothelial growth factor receptor involved in stimulating angiogenic processes. However Tat by itself or HHV8-genes alone cannot induce angiogenesis in vivo unless specific proteins enzymes are produced synchronously by different cell-types. We therefore tested a hypothesis that chronic HIV-replication in non-endothelial cells may produce novel factors that provoke angiogenic pathways. Methods Genome-wide proteins from HIV-infected and uninfected T-lymphocytes .