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ETIOLOGY AND PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

There has been a case report of exaggerated pigmented granulomatous reaction to the artificial joint implant in a 72-year-old man who had undergone bilateral total hip arthroplasty, in whom, aspirate from the inguinal region was misinterpreted as metastatic melanoma from an unknown primary. Microscopically, the smears of this patient showed both intracellular and extracellular black pigment with obscured cytomorphology; although, appreciable cells were reported to be pleomorphic with prominent nucleoli. The patient had no evidence of primary cutaneous melanoma. On surgical exploration and histologic examination, what was presumed to be the bulky enlarged lymph nodes was found to be the soft tissue with pigment-laden macrophages and granulomatous reaction that. | ETIOLOGY AND PATHOPHYSIOLOGY OF PARKINSON S DISEASE Edited by Abdul Qayyum Rana INTECHWEB.ORG Etiology and Pathophysiology of Parkinson s Disease Edited by Abdul Qayyum Rana Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Silvia Vlase Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Wouter Tolenaars 2011. Used under license from Shutterstock.com First published September 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Etiology and Pathophysiology of Parkinson s Disease Edited by Abdul Qayyum Rana p. cm. 978-953-307-462-7 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of .