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Báo cáo y học: "Global analysis of mRNA stability in the archaeon Sulfolobus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Global analysis of mRNA stability in the archaeon Sulfolobus. | Open Access Research Global analysis of mRNA stability in the archaeon Sulfolobus Anders F Andersson Magnus Lundgren Stefan Eriksson Magnus Rosenlund Rolf Bernander and Peter Nilsson Addresses Department of Gene Technology School of Biotechnology KTH - Royal Institute of Technology AlbaNova University Center SE-106 91 Stockholm Sweden. Department of Earth and Planetary Science University of California Berkeley Berkeley CA 94720-4767 USA. Department of Molecular Evolution Evolutionary Biology Center Uppsala University SE-752 36 Uppsala Sweden. Department of Mathematics KTH - Royal Institute of Technology SE-100 44 Stockholm Sweden. Correspondence Anders F Andersson. Email anders@eps.berkeley.edu Published 26 October 2006 Genome Biology 2006 7 R99 doi l0.ll86 gb-2006-7-l 0-r99 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 10 R99 Received 1 March 2006 Revised 11 October 2006 Accepted 26 October 2006 2006 Andersson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transcript half-lives differ between organisms and between groups of genes within the same organism. The mechanisms underlying these differences are not clear nor are the biochemical properties that determine the stability of a transcript. To address these issues genome-wide mRNA decay studies have been conducted in eukaryotes and bacteria. In contrast relatively little is known about RNA stability in the third domain of life Archaea. Here we present a microarray-based analysis of mRNA half-lives in the hyperthermophilic crenarchaea Sulfolobus solfataricus and Sulfolobus acidocaldarius constituting the first genome-wide study of RNA decay in archaea. Results The two .