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Báo cáo sinh học: " Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep | Genet. Sel. Evol. 39 2007 421-430 INRA EDP Sciences 2007 DOI 10.1051 gse 2007012 Available online at www.gse-journal.org Original article Quantitative trait loci linked to PRNP gene controlling health and production traits in INRA 401 sheep Zulma G. VlTEZICAa b Carole R. M0REN0b Frederic LANTIERd Isabelle LANTIERd Laurent SCHIBLERe Anne R0IGe Dominique Franc0ISb Jacques B0UIXb Daniel ALLAINb Jean-Claude BRUNELc Francis BARILLETb Jean-Michel ELSENb a INSERM U.563 CHU Purpan BP 3028 31024 Toulouse Cedex France b INRA UR631 Station d amelioration génétique des animaux 31326 Castanet-Tolosan France c INRA UE332 Domaine de Bourges-La Sapinière 18390 Osmoy France dINRA UR1282 Unite d infectiologie animale et santé publique 37380 Nouzilly France e INRA UR339 Unité de génétique biochimique et cytogénétique 78350 Jouy-en-Josas France Received 7 September 2006 accepted 20 February 2007 Abstract - In this study the potential association of PrP genotypes with health and productive traits was investigated. Data were recorded on animals of the INRA 401 breed from the Bourges-La Sapinière INRA experimental farm. The population consisted of 30 rams and 852 ewes which produced 1310 lambs. The animals were categorized into three PrP genotype classes ARR homozygous ARR heterozygous and animals without any ARR allele. Two analyses differing in the approach considered were carried out. Firstly the potential association of the PrP genotype with disease Salmonella resistance and production wool and carcass traits was studied. The data used included 1042 1043 and 1013 genotyped animals for the Salmonella resistance wool and carcass traits respectively. The different traits were analyzed using an animal model where the PrP genotype effect was included as a fixed effect. Association analyses do not indicate any evidence of an effect of PrP genotypes on traits studied in this breed. Secondly a quantitative trait loci QTL detection approach using the PRNP gene as a marker was applied on ovine